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| Title: | Molecular Seismology: An inverse problem in nanobiology. |
| Authors: | Hinow, Peter
Boczko, Erik M. |
| Keywords: | DNA-protein interactions
DNA binding kinetics
density inversion
DNA-ligand interactions
Inverse problems (Differential equations)
single molecule studies
wave equation |
| Issue Date: | 12-Sep-2006 |
| Publisher: | Vanderbilt University |
| Series/Report no.: | DBMI Technical Reports
091206 |
| Abstract: | The density profile of an elastic fiber like DNA will change in space and time as
ligands associate with it. This observation affords a new direction in single molecule
studies provided that density profiles can be measured in space and time. In fact, this
is precisely the objective of seismology, where the mathematics of inverse problems
have been employed with success. We argue that inverse problems in elastic media
can be directly applied to biophysical problems of fiber-ligand association, and demonstrate that
robust algorithms exist to perform density reconstruction in the condensed phase. |
| URI: | http://hdl.handle.net/1803/153 |
| Appears in Collections: | Technical Reports
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